+86-13524779951 sales@x-mobio.com
Products
  APIs
  Anti-tumor series
  Antithrombotic series
  Anti-HCV series
  Rheumatism series
  Anti-diabetic series
  Nervous system series
  Others
  Intermediates
  Featured products
  Others

This product is in stock,please ask for price.
If you have any question, please send the email to sales@x-mobio.com for the availability.We will reply to you as soon as possible.
Shipment: Products are shipped via FedEx Express.
Products
Description
GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50=0.8 nM (Wnt3a Co-culture RGA). GNF-6231 demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer. 
Chemical Structure
 
Chemical Name
N-[5-(4-Acetyl-piperazin-1-yl)-pyridin-2-yl]-2-(2'-fluoro-3-methyl-[2,4']bipyridinyl-5-yl)-acetamide 
SMILES Code
O=C(NC1=NC=C(N2CCN(C(C)=O)CC2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=F 
Theoretical Analysis
XingMo Cat#:XM018 
Product Name:GNF-6231 
Synonyms:GNF-6231; GNF 6231; GNF6231 
CAS#:1243245-18-2 
Chemical Formula:C24H25FN6O2 
Exact Mass:448.20 
Molecular Weight:448.49 
Purity:>98% 
Technical Data

Appearance: Solid powder  

Purity:>98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 for short term (days to weeks) or -20 for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). 

 



WARNING: This product is for research use only, not for human or veterinary use

Tel: +8613524779951  QQ: 点击这里给我发消息
Email: sales@x-mobio.com   Web: www.x-mobio.com  沪ICP备17047952号-1
Copyright 2017 Shanghai xingMo Biotechnology Co., Ltd. All rights reserved. Supported by www.hxchem.net