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Description
NU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. 
Chemical Structure
 
Chemical Name
8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one 
SMILES Code
O=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=CC=C4)C=CC=C13 
Theoretical Analysis
XingMo Cat#:XM032 
Product Name:NU7441 
Synonyms:NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. 
CAS#:503468-95-9 
Chemical Formula:C25H19NO3S 
Exact Mass:413.10856 
Molecular Weight:413.49 
Technical Data

Appearance: Solid powder   

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (mo

 



WARNING: This product is for research use only, not for human or veterinary use

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