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Momelotinib, also known as CYT387, is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions. 
Chemical Structure
Chemical Name
Theoretical Analysis
XingMo Cat#:XM085 
Product Name:Momelotinib (CYT387) 
Synonyms:CTY387; CYT-387; CYT 387; CYT11387; CYT-11387; CYT 11387; Momelotinib. 
Chemical Formula:C23H22N6O2 
Exact Mass:414.18042 
Molecular Weight:414.46 
Technical Data

Appearance: Yellow solid powder      

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4o C for short term (days to weeks) or -20o C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).


WARNING: This product is for research use only, not for human or veterinary use

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