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Description
Spebrutinib, also known as AVL-292 or CC-292, is an orally bioavailable, selective inhibitor of BrutonÂ’s agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. By irreversibly inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell proliferation of B-cell malignancies. 
Chemical Structure
 
Chemical Name
N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide 
SMILES Code
C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(OCCOC)C=C3)=NC=C2F)=C1)=O 
Theoretical Analysis
XingMo Cat#:XM006 
Product Name:Spebrutinib (AVL-292) 
Synonyms:CC292; CC-292; CC 292; AVL292; AVL-292; AVL 292. 
CAS#:1202757-89-8 
Chemical Formula:C22H22FN5O3 
Exact Mass:423.17067 
Molecular Weight:423.44 
Purity:>98% 
Technical Data

Appearance: White solid powder
Purity:>98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 for short term (days to weeks) or -20 for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 for short term (days to weeks), or -20 for long term (months).

 



WARNING: This product is for research use only, not for human or veterinary use

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