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Description
GW5074 is a c-Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis-associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington’s disease. GW5074 could have therapeutic value against neurodegenerative pathologies in humans. 
Chemical Structure
 
Chemical Name
3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one 
SMILES Code
O=C1NC2=C(C=C(I)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3  
Theoretical Analysis
XingMo Cat#:XM061 
Product Name:GW5074 
Synonyms:GW5074; GW 5074; GW-5074; 
CAS#:220904-83-6 
Chemical Formula:C15H8Br2INO2 
Exact Mass:518.79665 
Molecular Weight:520.94 
Technical Data

Appearance: solid powder   

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4o C for short term (days to weeks) or -20o C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). 

 



WARNING: This product is for research use only, not for human or veterinary use

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