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Description
MK-0812 is a potent and selective CCR2 antagonist. Chemokine (C-C motif) receptor 2 (CCR2) is central for the migration of monocytes into inflamed tissues. The inhibition of CCR2 signaling represents a potential therapeutic approach for treatment of metastasis without affecting homeostatic functions. 
Chemical Structure
 
Chemical Name
((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)(3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)methanone 
SMILES Code
CC(C)[C@@]1(CC[C@H](C1)N[C@H]2CCOC[C@H]2OC)C(=O)N3CCC4=NC=C(C=C4C3)C(F)(F)F 
Theoretical Analysis
XingMo Cat#:XM064 
Product Name:MK-0812 
Synonyms:MK-0812; MK 0812; MK0812 
CAS#:624733-88-6 
Chemical Formula:C24H34F3N3O3 
Exact Mass:469.2552 
Molecular Weight:469.5492 
Purity:>98% 
Technical Data

Appearance: solid powder   

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4o C for short term (days to weeks) or -20o C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). 

 



WARNING: This product is for research use only, not for human or veterinary use

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