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Description
SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. SBI-756 also suppressed AKT and NF-κB signaling.1) SBI-756 inhibited the growth of NRAS, BRAF, and NF1-mutant melanomas .2) SBI-756 attenuates resistance to BRAFi and inhibits NRAS- and NF1-mutant melanomas.3) SBI-756 delayed the onset and reduced the incidence of Nras/Ink4a melanomas. 
Chemical Structure
 
Theoretical Analysis
XingMo Cat#:XM129 
Product Name:SBI0640756 
Synonyms:SBI0640756; SBI 0640756,SBI-0640756; SBI756 
Molecular Weight:404.82 
Technical Data

Appearance: solid powder         

Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly.

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months). 

 



WARNING: This product is for research use only, not for human or veterinary use

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