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Description
LY 411575, also known as LSN-411575, is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. The gamma secretase inhibitor, activating pPKC alpha intracellular pathway could be suggested to prevent or reduce downstream toxic events, representing a useful strategy to counteract Alzheimer’s disease. 
Chemical Structure
 
Chemical Name
N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide 
SMILES Code
C[C@@H](C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C)C1=O)=O)NC([C@H](C4=CC(F)=CC(F)=C4)O)=O 
Theoretical Analysis
XingMo Cat#:XM195 
Product Name:LY-411575 
Synonyms:LY 411575; LY-411575; LY411575; LSN-411575; LSN 411575; LSN411575. 
CAS#:209984-57-6 
Chemical Formula:C26H23F2N3O4 
Exact Mass:479.1657 
Molecular Weight:479.4838 
Technical Data
Appearance: Solid powder               
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years)
Solubility: Soluble in DMSO, not in water
Shelf Life:
>2 years if stored properly.
Drug Formulation:
This drug may be formulated in DMSO
Stock Solution Storage:
0 - 4oC for short term (days to weeks), or -20oC for long term (months). 
 



WARNING: This product is for research use only, not for human or veterinary use

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