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  原料药
  抗癌类
  抗血栓类
  丙肝类
  风湿类
  糖尿病类
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产品介绍
产品描述
LGK974, aslo known as is a selective and orally bioavailable Porcupine (PORCN) inhibitor under development for the treatment of cancers that are driven by the Wnt pathway in a Wnt ligand-dependent manner. WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers. 
化学结构
 
化学名称
2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide 
SMILES Code
O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3 
基本信息
产品编号:XM025 
产品名称:LGK974 (WNT974) 
别名:LGK974; LGK-974; LGK 974; WNT974; WNT 974; WNT-974. 
CAS#:1243244-14-5 
分子式:C23H20N6O 
精确分子量:396.16986 
分子量:396.44 
纯度:>98% 
物化性质

外观: 白色固体 

纯度: >98%

运输信息: 非危险化学品,适于常温或冰袋运输。

储存条件: 低温,干燥,避光。

溶解性:   溶于DMSO, 不溶于水

储存期限:3 年-20℃ 固体储存

                 2 年  -80℃ 溶液储存

 



该产品只供科研使用,不能给病人提供。

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