+86-13524779951 sales@x-mobio.com
产品类别
  原料药
  抗癌类
  抗血栓类
  丙肝类
  风湿类
  糖尿病类
  神经系统类
  其他
  中间体
  特色产品
  其他

产品介绍
产品描述
AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes. 
化学结构
 
化学名称
calcium (S)-3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)hex-4-ynoate hydrate 
SMILES Code
CC#C[C@@H](CC([O-])=O)C1=CC=C(C=C1)OCC2=CC(C3=CC=C(C=C3)C(F)(F)F)=CC=C2.CC#C[C@@H](CC([O-])=O)C4=CC=C(C=C4)OCC5=CC(C6=CC=C(C=C6)C(F)(F)F)=CC=C5.[H]O[H].[Ca+2] 
基本信息
产品编号:XM002 
产品名称:AMG-837 calcium salt hydrate 
别名:AMG837; AMG-837; AMG 837 
CAS#:1259389-38-2 (calium salt hydrate) 
分子式:C52H42CaF6O7 
分子量:932.9694 
物化性质

外观: 固体粉末

纯度: >98%

运输信息: 非危险化学品,适于常温环境下运输。

储存条件: 低温,干燥,避光。

溶解性:   溶于DMSO, 不溶于水

储存期限: 3 年-20℃  固体储存

          2 年  -80℃ 溶于储存

 



该产品只供科研使用,不能给病人提供。

电话: +8613524779951  QQ: 点击这里给我发消息
Email: sales@x-mobio.com   Web: www.x-mobio.com  沪ICP备17047952号-1
版权所有© 2017 上海兴默生物技术有限公司     技术支持:华夏化工网 后台管理  企业邮箱