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产品介绍
产品描述
Losmapimod, also know as GW856553 or GW856553X, is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases. p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway. Inhibiting these enzymes has been shown to produce antidepressant and antipsychotic effects in animal studies, with the mechanism thought to involve increased neurogenesis probably related to BDNF release. Losmapimod has completed Phase II human clinical trials for the treatment of depression although its safety and efficacy have yet to be proven in further trials. Losmapimod is also being studied for cardiovascular disease. A Phase II trial to study its effects in myocardial infarction (heart attack) is ongoing. (source: http://en.wikipedia.org/wiki/Losmapimod). 
化学结构
 
化学名称
6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide. 
SMILES Code
O=C(C1=CC=C(C2=CC(C(NC3CC3)=O)=CC(F)=C2C)N=C1)NCC(C)(C)C 
基本信息
产品编号:XM380 
产品名称:Losmapimod (GW856553) 
别名:Losmapimod; GW856553; GW-856553; GW 856553 
CAS#:585543-15-3 
分子式:C22H26FN3O2 
精确分子量:383.20091 
分子量:383.46 
物化性质

外观: 白色固体粉末

纯度: >98%

运输信息: 非危险化学品,适于常温或冰袋运输。

储存条件: 低温,干燥,避光。

溶解性:   溶于DMSO, 不溶于水

储存期限:3年 -20℃固体储存

         2 年  -80℃ 溶液储存

 



该产品只供科研使用,不能给病人提供。

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