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产品介绍
产品描述
Apimostinel, also known as NRX-1074, also known as AGN-241660, is a novel antidepressant, acting as a selective partial agonist of an allosteric site of the glycine site of the NMDA receptor complex, which is under investigation by Naurex (recently acquired by Allergan) for the treatment of major depressive disorder. Its mechanism of action and effects are similar to those of rapastinel (GLYX-13), which is under development as an adjunctive therapy for treatment-resistant depression also by Naurex; however, NRX-1074 is 100-fold more potent by weight and, unlike GLYX-13 (which must be administered via intravenous injection), is orally-active. 
化学结构
 
化学名称
(2R)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-2-benzylpyrrolidine-2-carboxamide 
SMILES Code
O=C([C@@]1(CC2=CC=CC=C2)N(C([C@H]3N(C([C@@H](N)[C@H](O)C)=O)CCC3)=O)CCC1)N[C@@H]([C@H](O)C)C(N)=O 
基本信息
产品编号:XM433 
产品名称:Apimostinel 
别名:NRX-1074; NRX 1074; NRX1074; AGN-241660; AGN241660; AGN 241660. Apimostinel 
CAS#:1421866-48-9 
分子式:C25H37N5O6 
精确分子量:503.2744 
分子量:503.6 
物化性质

外观: 固体粉末

纯度: >98%

运输信息: 非危险化学品,适于常温或冰袋运输。

储存条件: 低温,干燥,避光。

溶解性:   溶于DMSO, 不溶于水

储存期限:3年 -20℃固体储存

         2 年  -80℃ 溶液储存

 



该产品只供科研使用,不能给病人提供。

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