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产品类别
  原料药
  抗癌类
  抗血栓类
  丙肝类
  风湿类
  糖尿病类
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产品介绍
产品描述
AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes. 
化学结构
 
化学名称
(S)-3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)hex-4-ynoate 
基本信息
产品编号:XM709 
产品名称:AMG-837 
别名:AMG-837, AMG837 
CAS#:865231-46-5 
分子式:C26H21F3O3 
精确分子量:438.53 
分子量:438.44 
纯度:>98% 
物化性质



该产品只供科研使用,不能给病人提供。

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