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产品类别
  原料药
  抗癌类
  抗血栓类
  丙肝类
  风湿类
  糖尿病类
  神经系统类
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产品介绍
产品描述
Vafidemstat (ORY-2001) is an oral and brain penetrant drug that selectively inhibits LSD1 and MAOB. The molecule acts on several levels, reduces cognitive impairment, memory loss and neuroinflammation, and at the same time has neuroprotective effects. The company has recently reported in several scientific conferences that in preclinical models Vafidemstat exerts a holistic action on different types of alterations also seen in patients with AD and other neurodegenerative disorders. Different experiments suggest Vafidemstat may act as a disease modifying drug. In AD patients and other neurodegenerative disorders, cognitive deterioration is often accompanied by episodes of agitation, aggression, psychosis, apathy and depression. In preclinical studies, Vafidemstat not only restores memory but reduces the exacerbated aggressiveness of SAMP8 mice, a model for accelerated aging and Alzheimer’s disease, to normal levels and also reduces social avoidance and enhances sociability in various murine models. In addition, Vafidemstat exhibits fast, strong and durable efficacy in several preclinical models of multiple sclerosis (MS). The company has already started Phase IIa clinical studies with Vafidemstat in patients with Relapse-Remitting and Secondary Progressive MS (SATEEN) and in patients with Mild to Moderate Alzheimer’s disease (ETHERAL) 
化学结构
 
化学名称
1,3,4-Oxadiazole-2-methanamine, 5-amino-N-[(1R,2S)-2-[4-(phenylmethoxy)phenyl]cyclopropyl]- 
基本信息
产品编号:XM771 
产品名称:Vafidemstat 
别名:Vafidemstat(ORY-2001,ORY2001) 
CAS#:1357362-02-7 
分子式:C19H20N4O2 
精确分子量:336.1586 
分子量:336.4 
纯度:98% 
物化性质

外观: 固体粉末

纯度: >98%

运输信息: 非危险化学品,适于常温或冰袋运输。

储存条件: 低温,干燥,避光。

溶解性:   溶于DMSO, 不溶于水

储存期限:3年 -20℃固体储存

         2 年  -80℃ 溶液储存

 



该产品只供科研使用,不能给病人提供。

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